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Nutritional Supplement

Neem

  • Oral Health

    Gingivitis

    Neem gel has been shown to be effective at reducing plaque and bacterial levels in the mouth.
    Gingivitis
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    In a double-blind trial, 1 gram of neem leaf extract in gel twice per day was more effective than chlorhexidine or placebo gel at reducing plaque and bacteria levels in the mouth in 36 Indian adults.3 A similar trial found neem gel superior to placebo and equally effective as chlorhexidine at reducing plaque and bacteria levels in the mouth.4

    Tooth Decay

    Neem leaf extract has been shown to reduce plaque and bacteria levels in the mouth.
    Tooth Decay
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    In a double-blind trial, 1 gram of neem leaf extract in gel twice per day was more effective than chlorhexidine or placebo gel at reducing plaque and bacteria levels in the mouth in 36 Indian adults.5 A similar trial found neem gel superior to placebo and equally effective as chlorhexidine at reducing plaque and bacteria levels in the mouth.6 These promising early studies should be followed by studies regarding prevention of cavities and relief from gingivitis or periodontal disease.

  • Digestive Support

    Peptic Ulcer

    Neem bark extract led to a significant reduction in stomach acid levels and near complete healing of all people with duodenal ulcers in one trial.
    Peptic Ulcer
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    Administration of 30 to 60 mg of freeze-dried neem bark extract twice per day led to a significant reduction in stomach acid levels and near complete healing of all people with duodenal ulcers over ten weeks time in a preliminary clinical trial.7

    Chamomile has a soothing effect on inflamed and irritated mucous membranes. It is also high in the flavonoid apigenin—another flavonoid that has inhibited growth of H. pylori in test tubes.8 Many doctors recommend drinking two to three cups of strong chamomile tea each day. The tea can be made by combining 3 to 5 ml of chamomile tincture with hot water or by steeping 2 to 3 tsp of chamomile flowers in the water, covered, for 10 to 15 minutes. Chamomile is also available in capsules; two may be taken three times per day.

  • Women's Health

    Vaginitis

    In one trial, a cream containing neem seed extract, saponins of reetha, and quinine hydrochloride eliminated all symptoms in 10 of 14 women with chlamydia.
    Vaginitis
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    In a double-blind, placebo-controlled trial, a cream containing neem seed extract, saponins of Sapindus mukerossi (reetha), and quinine hydrochloride (5 ml applied vaginally once at bedtime) eliminated all symptoms in 10 of 14 women with chlamydia compared with none of four women given placebo cream.9 Neither cream was effective in women with trichomoniasis or candidal vaginitis.

What Are Star Ratings?
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Reliable and relatively consistent scientific data showing a substantial health benefit.
Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

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Traditional Use (May Not Be Supported by Scientific Studies)

Neem has a long history of use in the traditional medical systems of India (Ayurvedic, Unani-Tibb).10 Neem leaf and bark extracts are most consistently recommended in ancient medical texts and by herbal practitioners for gastrointestinal upsets, diarrhea and intestinal infections, skin ulcers and infections, and malaria.10 Neem twigs are the most regularly used toothbrush for a large portion of the population of India and other countries where the tree is common.12 The effectiveness of many of these uses has been confirmed in modern research studies, showing, for example, that neem bark extracts are effective for people with stomach ulcers, that leaf gel can effectively fight periodontal disease, and that leaf extracts can combat scabies infections.13,14,15 The claimed contraceptive effects of neem have been confirmed in some animal studies showing that seed extracts of neem are spermicidal.16

References

1. Rembold H. The azadirachtins—their potential for insect control. Econ Med Plant Res 1989;3:57-72.

2. Schmutterer H, Ascher KRS, Isman MB, et al, eds. The Neem Tree:Azadirachta indicaA Juss and Other Meliaceous Plants. Weinheim, Germany: VCH, 1995.

3. Pai MR, Acharya LD, Udupa N. Evaluation of antiplaque activity of Azadirachta indica leaf extract gel—a 6-week clinical study. J Ethnopharmacol2004;90:99-103.

4. Pai MR, Acharya LD, Udupa N. The effect of two different dental gels and a mouthwash on plaque and gingival scores: a six-week clinical study. Int Dent J 2004;54:219-23.

5. Pai MR, Acharya LD, Udupa N. Evaluation of antiplaque activity of Azadirachta indica leaf extract gel—a 6-week clinical study. J Ethnopharmacol2004;90:99-103.

6. Pai MR, Acharya LD, Udupa N. The effect of two different dental gels and a mouthwash on plaque and gingival scores: a six-week clinical study. Int Dent J 2004;54:219-23.

7. Bandyopadhyay U, Biswas K, Sengupta A, et al. Clinical studies on the effect of Neem (Azadirachta indica) bark extract on gastric secretion and gastroduodenal ulcer. Life Sci2004;75:2867-78.

8. Beil W, Birkholz C, Sewing KF. Effects of flavonoids on parietal cell acid secretion, gastric mucosal prostaglandin production and Helicobacter pylori growth. Arzneimittelforschung 1995;45:697-700.

9. Mittal A, Kapur s, Garg S, et al. Clinical trial with Praneem polyherbal cream in patients with abnormal vaginal discharge due to microbial infections. Aust NZ J Obstet Gynaecol1995;35:190-1.

10. Schmutterer H, Ascher KRS, Isman MB, et al, eds. The Neem Tree:Azadirachta indicaA Juss and Other Meliaceous Plants. Weinheim, Germany: VCH, 1995.

11. Ad Hoc Panel of the Board on Science and Technology for International Development, National Research Council. Neem: A Tree for Solving Global Problems. Washington, DC: National Academy Press, 1992.

12. Bandyopadhyay U, Biswas K, Sengupta A, et al. Clinical studies on the effect of Neem (Azadirachta indica) bark extract on gastric secretion and gastroduodenal ulcer. Life Sci2004;75:2867-78.

13. Pai MR, Acharya LD, Udupa N. The effect of two different dental gels and a mouthwash on plaque and gingival scores: a six-week clinical study. Int Dent J 2004;54:219-23.

14. Charles V, Charles SX. The use and efficacy of Azadirachta indica ADR ('Neem') and Curcuma longa ('Turmeric') in scabies. A pilot study. Trop Geogr Med 1992;44:178-81.

15. Garg S, Taluja V, Upadhyay SN, Talwar GP. Studies on the contraceptive efficacy of Praneem polyherbal cream. Contraception1993;48:591-6.

16. Khare CP. Indian Herbal Remedies. Berlin: Springer, 2004.

17. Pai MR, Acharya LD, Udupa N. Evaluation of antiplaque activity of Azadirachta indica leaf extract gel—a 6-week clinical study. J Ethnopharmacol2004;90:99-103.

18. Bandyopadhyay U, Biswas K, Sengupta A, et al. Clinical studies on the effect of Neem (Azadirachta indica) bark extract on gastric secretion and gastroduodenal ulcer. Life Sci2004;75:2867-78.

19. Mishra AK, Singh N, Sharma VP. Use of neem oil as a mosquito repellent in tribal villages of Mandla district, Madhya Pradesh. Indian J Malariol 1995;32:99-103.

20. Sinniah D, Baskara G, Looi LM, Leong KL. Reye-like syndrome due to margosa oil poisoning: Report of a case with postmortem findings. Am J Gastroenterol 1982;77:158-61.

21. Caius JF, Mhaskar KS. The correlation between the chemical composition of anthelminthics and their therapeutic values in connection with the hookworm inquiry in the Madras Presidency. Indian J Med Res 1923;11:353-70.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2020.

Copyright © 2020 TraceGains, Inc. All rights reserved.

The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2020.