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Nutritional Supplement

Copper

  • Negative Interactions

    12
    • Copper

      Ciprofloxacin

      Reduces Effectiveness

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Minerals such as aluminum, calcium, copper, iron, magnesium, manganese, and zinc can bind to ciprofloxacin, greatly reducing the absorption of the drug. Because of the mineral content, people are advised to take ciprofloxacin two hours after consuming dairy products (milk, cheese, yogurt, ice cream, and others), antacids (Maalox®, Mylanta®, Tums®, Rolaids®, and others), and mineral-containing supplements.

      Ciprofloxacin
      Copper
      ×
      1. Campbell NR, Hasinoff BB. Iron supplements: A common cause of drug interactions. Br J Clin Pharmacol 1991;31:251-5.
      2. Lim D, McKay M. Food-drug interactions. Drug Information Bull 1995;15(2) [review].
      3. Threlkeld DS, ed. Systemic Anti-Infectives, Fluoroquinolones. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1994, 340n-40o.
      4. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 74.
    • Copper

      Ciprofloxacin in D5W

      Reduces Effectiveness

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Minerals such as aluminum, calcium, copper, iron, magnesium, manganese, and zinc can bind to ciprofloxacin, greatly reducing the absorption of the drug. Because of the mineral content, people are advised to take ciprofloxacin two hours after consuming dairy products (milk, cheese, yogurt, ice cream, and others), antacids (Maalox®, Mylanta®, Tums®, Rolaids®, and others), and mineral-containing supplements.

      Ciprofloxacin in D5W
      Copper
      ×
      1. Campbell NR, Hasinoff BB. Iron supplements: A common cause of drug interactions. Br J Clin Pharmacol 1991;31:251-5.
      2. Lim D, McKay M. Food-drug interactions. Drug Information Bull 1995;15(2) [review].
      3. Threlkeld DS, ed. Systemic Anti-Infectives, Fluoroquinolones. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1994, 340n-40o.
      4. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 74.
    • Copper

      Delafloxacin

      Reduces Effectiveness

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Minerals such as aluminum, calcium, copper, iron, magnesium, manganese, and zinc can bind to ciprofloxacin, greatly reducing the absorption of the drug. Because of the mineral content, people are advised to take ciprofloxacin two hours after consuming dairy products (milk, cheese, yogurt, ice cream, and others), antacids (Maalox®, Mylanta®, Tums®, Rolaids®, and others), and mineral-containing supplements.

      Delafloxacin
      Copper
      ×
      1. Campbell NR, Hasinoff BB. Iron supplements: A common cause of drug interactions. Br J Clin Pharmacol 1991;31:251-5.
      2. Lim D, McKay M. Food-drug interactions. Drug Information Bull 1995;15(2) [review].
      3. Threlkeld DS, ed. Systemic Anti-Infectives, Fluoroquinolones. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1994, 340n-40o.
      4. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 74.
    • Copper

      Gatifloxacin

      Reduces Effectiveness

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Minerals such as aluminum, calcium, copper, iron, magnesium, manganese, and zinc can bind to ciprofloxacin, greatly reducing the absorption of the drug. Because of the mineral content, people are advised to take ciprofloxacin two hours after consuming dairy products (milk, cheese, yogurt, ice cream, and others), antacids (Maalox®, Mylanta®, Tums®, Rolaids®, and others), and mineral-containing supplements.

      Gatifloxacin
      Copper
      ×
      1. Campbell NR, Hasinoff BB. Iron supplements: A common cause of drug interactions. Br J Clin Pharmacol 1991;31:251-5.
      2. Lim D, McKay M. Food-drug interactions. Drug Information Bull 1995;15(2) [review].
      3. Threlkeld DS, ed. Systemic Anti-Infectives, Fluoroquinolones. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1994, 340n-40o.
      4. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 74.
    • Copper

      Gatifloxacin in D5W

      Reduces Effectiveness

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Minerals such as aluminum, calcium, copper, iron, magnesium, manganese, and zinc can bind to ciprofloxacin, greatly reducing the absorption of the drug. Because of the mineral content, people are advised to take ciprofloxacin two hours after consuming dairy products (milk, cheese, yogurt, ice cream, and others), antacids (Maalox®, Mylanta®, Tums®, Rolaids®, and others), and mineral-containing supplements.

      Gatifloxacin in D5W
      Copper
      ×
      1. Campbell NR, Hasinoff BB. Iron supplements: A common cause of drug interactions. Br J Clin Pharmacol 1991;31:251-5.
      2. Lim D, McKay M. Food-drug interactions. Drug Information Bull 1995;15(2) [review].
      3. Threlkeld DS, ed. Systemic Anti-Infectives, Fluoroquinolones. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1994, 340n-40o.
      4. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 74.
    • Copper

      Gemifloxacin

      Reduces Effectiveness

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Minerals such as aluminum, calcium, copper, iron, magnesium, manganese, and zinc can bind to ciprofloxacin, greatly reducing the absorption of the drug. Because of the mineral content, people are advised to take ciprofloxacin two hours after consuming dairy products (milk, cheese, yogurt, ice cream, and others), antacids (Maalox®, Mylanta®, Tums®, Rolaids®, and others), and mineral-containing supplements.

      Gemifloxacin
      Copper
      ×
      1. Campbell NR, Hasinoff BB. Iron supplements: A common cause of drug interactions. Br J Clin Pharmacol 1991;31:251-5.
      2. Lim D, McKay M. Food-drug interactions. Drug Information Bull 1995;15(2) [review].
      3. Threlkeld DS, ed. Systemic Anti-Infectives, Fluoroquinolones. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1994, 340n-40o.
      4. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 74.
    • Copper

      Levofloxacin

      Reduces Effectiveness

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Minerals such as aluminum, calcium, copper, iron, magnesium, manganese, and zinc can bind to ciprofloxacin, greatly reducing the absorption of the drug. Because of the mineral content, people are advised to take ciprofloxacin two hours after consuming dairy products (milk, cheese, yogurt, ice cream, and others), antacids (Maalox®, Mylanta®, Tums®, Rolaids®, and others), and mineral-containing supplements.

      Levofloxacin
      Copper
      ×
      1. Campbell NR, Hasinoff BB. Iron supplements: A common cause of drug interactions. Br J Clin Pharmacol 1991;31:251-5.
      2. Lim D, McKay M. Food-drug interactions. Drug Information Bull 1995;15(2) [review].
      3. Threlkeld DS, ed. Systemic Anti-Infectives, Fluoroquinolones. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1994, 340n-40o.
      4. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 74.
    • Copper

      Levofloxacin in D5W

      Reduces Effectiveness

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Minerals such as aluminum, calcium, copper, iron, magnesium, manganese, and zinc can bind to ciprofloxacin, greatly reducing the absorption of the drug. Because of the mineral content, people are advised to take ciprofloxacin two hours after consuming dairy products (milk, cheese, yogurt, ice cream, and others), antacids (Maalox®, Mylanta®, Tums®, Rolaids®, and others), and mineral-containing supplements.

      Levofloxacin in D5W
      Copper
      ×
      1. Campbell NR, Hasinoff BB. Iron supplements: A common cause of drug interactions. Br J Clin Pharmacol 1991;31:251-5.
      2. Lim D, McKay M. Food-drug interactions. Drug Information Bull 1995;15(2) [review].
      3. Threlkeld DS, ed. Systemic Anti-Infectives, Fluoroquinolones. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1994, 340n-40o.
      4. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 74.
    • Copper

      Moxifloxacin

      Reduces Effectiveness

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Minerals such as aluminum, calcium, copper, iron, magnesium, manganese, and zinc can bind to ciprofloxacin, greatly reducing the absorption of the drug. Because of the mineral content, people are advised to take ciprofloxacin two hours after consuming dairy products (milk, cheese, yogurt, ice cream, and others), antacids (Maalox®, Mylanta®, Tums®, Rolaids®, and others), and mineral-containing supplements.

      Moxifloxacin
      Copper
      ×
      1. Campbell NR, Hasinoff BB. Iron supplements: A common cause of drug interactions. Br J Clin Pharmacol 1991;31:251-5.
      2. Lim D, McKay M. Food-drug interactions. Drug Information Bull 1995;15(2) [review].
      3. Threlkeld DS, ed. Systemic Anti-Infectives, Fluoroquinolones. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1994, 340n-40o.
      4. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 74.
    • Copper

      Moxifloxacin in Saline

      Reduces Effectiveness

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Minerals such as aluminum, calcium, copper, iron, magnesium, manganese, and zinc can bind to ciprofloxacin, greatly reducing the absorption of the drug. Because of the mineral content, people are advised to take ciprofloxacin two hours after consuming dairy products (milk, cheese, yogurt, ice cream, and others), antacids (Maalox®, Mylanta®, Tums®, Rolaids®, and others), and mineral-containing supplements.

      Moxifloxacin in Saline
      Copper
      ×
      1. Campbell NR, Hasinoff BB. Iron supplements: A common cause of drug interactions. Br J Clin Pharmacol 1991;31:251-5.
      2. Lim D, McKay M. Food-drug interactions. Drug Information Bull 1995;15(2) [review].
      3. Threlkeld DS, ed. Systemic Anti-Infectives, Fluoroquinolones. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1994, 340n-40o.
      4. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 74.
    • Copper

      Norfloxacin

      Reduces Effectiveness

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Minerals such as aluminum, calcium, copper, iron, magnesium, manganese, and zinc can bind to ciprofloxacin, greatly reducing the absorption of the drug. Because of the mineral content, people are advised to take ciprofloxacin two hours after consuming dairy products (milk, cheese, yogurt, ice cream, and others), antacids (Maalox®, Mylanta®, Tums®, Rolaids®, and others), and mineral-containing supplements.

      Norfloxacin
      Copper
      ×
      1. Campbell NR, Hasinoff BB. Iron supplements: A common cause of drug interactions. Br J Clin Pharmacol 1991;31:251-5.
      2. Lim D, McKay M. Food-drug interactions. Drug Information Bull 1995;15(2) [review].
      3. Threlkeld DS, ed. Systemic Anti-Infectives, Fluoroquinolones. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1994, 340n-40o.
      4. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 74.
    • Copper

      Ofloxacin

      Reduces Effectiveness

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      Minerals such as aluminum, calcium, copper, iron, magnesium, manganese, and zinc can bind to ciprofloxacin, greatly reducing the absorption of the drug. Because of the mineral content, people are advised to take ciprofloxacin two hours after consuming dairy products (milk, cheese, yogurt, ice cream, and others), antacids (Maalox®, Mylanta®, Tums®, Rolaids®, and others), and mineral-containing supplements.

      Ofloxacin
      Copper
      ×
      1. Campbell NR, Hasinoff BB. Iron supplements: A common cause of drug interactions. Br J Clin Pharmacol 1991;31:251-5.
      2. Lim D, McKay M. Food-drug interactions. Drug Information Bull 1995;15(2) [review].
      3. Threlkeld DS, ed. Systemic Anti-Infectives, Fluoroquinolones. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1994, 340n-40o.
      4. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 74.
  • Supportive Interactions

    46
    • Copper

      AZT

      Replenish Depleted Nutrients

      Preliminary human research suggests AZT therapy may cause a reduction in copper and zinc blood levels. The practical importance of these findings remains unclear.

    • Copper and Zinc

      Brivaracetam

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Brivaracetam
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Carbamazepine

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Carbamazepine
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Cenobamate

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Cenobamate
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper

      Cimetidine in Normal Saline

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      There is some evidence that other vitamins and minerals, such as folic acid and copper, require the presence of stomach acid for optimal absorption. Long-term use of H-2 blockers may therefore promote a deficiency of these nutrients. Individuals requiring long-term use of H-2 blockers may therefore benefit from a multiple vitamin/mineral supplement.

      Cimetidine in Normal Saline
      Copper
      ×
      1. Russell RM, Krasinski SD, Samloff IM. Correction of impaired folic acid (Pte Glu) absorption by orally administered HCl in subjects with gastric atrophy. Am J Clin Nutr 1984;39:656.
      2. Tompsett SL. Factors influencing the absorption of iron and copper from the alimentary tract. Biochem J 1940;34:961-9.
    • Copper and Zinc

      Clobazam

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Clobazam
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Clonazepam

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Clonazepam
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Diazepam

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Diazepam
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Divalproex

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Divalproex
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Eslicarbazepine

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Eslicarbazepine
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Ethosuximide

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Ethosuximide
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Ethotoin

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Ethotoin
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper

      Famotidine

      Replenish Depleted Nutrients

      Some evidence indicates that other vitamins and minerals, such as folic acid and copper, require the presence of stomach acid for optimal absorption. Long-term use of H-2 blockers may therefore promote a deficiency of these nutrients. Individuals requiring long-term use of H-2 blockers may therefore benefit from a multiple vitamin/mineral supplement.

      Famotidine
      Copper
      ×
      1. Russell RM, Krasinski SD, Samloff IM. Correction of impaired folic acid (Pte Glu) absorption by orally administered HCl in subjects with gastric atrophy. Am J Clin Nutr 1984;39:656.
      2. Tompsett SL. Factors influencing the absorption of iron and copper from the alimentary tract. Biochem J 1940;34:961-9.
    • Copper

      Famotidine (PF)

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      There is some evidence that other vitamins and minerals, such as folic acid and copper, require the presence of stomach acid for optimal absorption. Long-term use of H-2 blockers may therefore promote a deficiency of these nutrients. Individuals requiring long-term use of H-2 blockers may therefore benefit from a multiple vitamin/mineral supplement.

      Famotidine (PF)
      Copper
      ×
      1. Russell RM, Krasinski SD, Samloff IM. Correction of impaired folic acid (Pte Glu) absorption by orally administered HCl in subjects with gastric atrophy. Am J Clin Nutr 1984;39:656.
      2. Tompsett SL. Factors influencing the absorption of iron and copper from the alimentary tract. Biochem J 1940;34:961-9.
    • Copper

      Famotidine in Normal Saline

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      There is some evidence that other vitamins and minerals, such as folic acid and copper, require the presence of stomach acid for optimal absorption. Long-term use of H-2 blockers may therefore promote a deficiency of these nutrients. Individuals requiring long-term use of H-2 blockers may therefore benefit from a multiple vitamin/mineral supplement.

      Famotidine in Normal Saline
      Copper
      ×
      1. Russell RM, Krasinski SD, Samloff IM. Correction of impaired folic acid (Pte Glu) absorption by orally administered HCl in subjects with gastric atrophy. Am J Clin Nutr 1984;39:656.
      2. Tompsett SL. Factors influencing the absorption of iron and copper from the alimentary tract. Biochem J 1940;34:961-9.
    • Copper and Zinc

      Felbamate

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Felbamate
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Fenfluramine

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Fenfluramine
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Folic Acid

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Folic Acid
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Fosphentyoin

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Fosphentyoin
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Gabapentin

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Gabapentin
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Lacosamide

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Lacosamide
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Lamotrigine

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Lamotrigine
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Levetiracetam

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Levetiracetam
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Methsuximide

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Methsuximide
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper

      Nizatidine

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      There is some evidence that other vitamins and minerals, such as folic acid and copper, require the presence of stomach acid for optimal absorption. Long-term use of H-2 blockers may therefore promote a deficiency of these nutrients. Individuals requiring long-term use of H-2 blockers may therefore benefit from a multiple vitamin/mineral supplement.

      Nizatidine
      Copper
      ×
      1. Russell RM, Krasinski SD, Samloff IM. Correction of impaired folic acid (Pte Glu) absorption by orally administered HCl in subjects with gastric atrophy. Am J Clin Nutr 1984;39:656.
      2. Tompsett SL. Factors influencing the absorption of iron and copper from the alimentary tract. Biochem J 1940;34:961-9.
    • Copper and Zinc

      Oxcarbazepine

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Oxcarbazepine
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Phenobarbital

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Phenobarbital
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Phenytoin

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Phenytoin
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Phenytoin Sodium Extended

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Phenytoin Sodium Extended
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Phenytoin Sodium Prompt

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Phenytoin Sodium Prompt
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Pregabalin

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Pregabalin
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Primidone

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Primidone
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper

      Ranitidine

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      There is some evidence that other vitamins and minerals, such as folic acid and copper, require the presence of stomach acid for optimal absorption. Long-term use of H-2 blockers may therefore promote a deficiency of these nutrients. Individuals requiring long-term use of H-2 blockers may therefore benefit from a multiple vitamin/mineral supplement.

      Ranitidine
      Copper
      ×
      1. Russell RM, Krasinski SD, Samloff IM. Correction of impaired folic acid (Pte Glu) absorption by orally administered HCl in subjects with gastric atrophy. Am J Clin Nutr 1984;39:656.
      2. Tompsett SL. Factors influencing the absorption of iron and copper from the alimentary tract. Biochem J 1940;34:961-9.
    • Copper and Zinc

      Rufinamide

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Rufinamide
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Tiagabine

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Tiagabine
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Topiramate

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Topiramate
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Trimethadione

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Trimethadione
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Valproate

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Valproate
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Valproic Acid

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Valproic Acid
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Vigabatrin

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Vigabatrin
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper and Zinc

      Zonisamide

      Replenish Depleted Nutrients

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal or decreased, serum copper levels remained normal or decreased, and red blood cell zinc levels were decreased. The importance of these changes and how frequently they occur remain unclear.

      Zonisamide
      Copper and Zinc
      ×
      1. Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992;33:555-7.
      2. Lerman-Sagie T, Statter M, Szabo G, Lerman P. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol 1987;10:80-6.
      3. Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol 1995;6:265-9.
    • Copper

      Drospirenone (Contraceptive)

      Support Medicine

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1, B2, B3, B12, C, and zinc levels. Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A. Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

      Drospirenone (Contraceptive)
      Copper
      ×
      1. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210-1 [review].
      2. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561-4.
      3. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197-8.
      4. Berg G, Kohlmeier L, Brenner H. Effect of oral contraceptive progestins on serum copper concentration. Eur J Clin Nutr 1998;52:711-5.
      5. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.
    • Copper

      Norethindrone (Contraceptive)

      Support Medicine

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1, B2, B3, B12, C, and zinc levels. Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A. Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

      Norethindrone (Contraceptive)
      Copper
      ×
      1. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210-1 [review].
      2. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561-4.
      3. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197-8.
      4. Berg G, Kohlmeier L, Brenner H. Effect of oral contraceptive progestins on serum copper concentration. Eur J Clin Nutr 1998;52:711-5.
      5. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.
    • Copper

      Norgestrel

      Support Medicine

      This interaction is based on this drug belonging to a drug class. While this drug may differ from the text and references below, drugs within this class work in a similar way and this interaction is applicable to drugs within the same class.

      A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1, B2, B3, B12, C, and zinc levels. Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A. Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

      Norgestrel
      Copper
      ×
      1. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210-1 [review].
      2. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561-4.
      3. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197-8.
      4. Berg G, Kohlmeier L, Brenner H. Effect of oral contraceptive progestins on serum copper concentration. Eur J Clin Nutr 1998;52:711-5.
      5. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.
    • Copper

      Oxaprozin

      Support Medicine

      Supplementation may enhance the anti-inflammatory effects of NSAIDs while reducing their ulcerogenic effects. One study found that when various anti-inflammatory drugs were chelated with copper, the anti-inflammatory activity was increased. Animal models of inflammation have found that the copper chelate of aspirin was active at one-eighth the effective dose of aspirin. These copper complexes are less toxic than the parent compounds, as well.

      Oxaprozin
      Copper
      ×
      1. Sorenson JRJ. Copper chelates as possible active forms of the antiarthritic agents. J Medicinal Chem 1976;19:135-48.
    • Copper

      Oxaprozin

      Reduce Side Effects

      Supplementation may enhance the anti-inflammatory effects of NSAIDs while reducing their ulcerogenic effects. One study found that when various anti-inflammatory drugs were chelated with copper, the anti-inflammatory activity was increased. Animal models of inflammation have found that the copper chelate of aspirin was active at one-eighth the effective dose of aspirin. These copper complexes are less toxic than the parent compounds, as well.

      Oxaprozin
      Copper
      ×
      1. Sorenson JRJ. Copper chelates as possible active forms of the antiarthritic agents. J Medicinal Chem 1976;19:135-48.
  • Explanation Required

    9
    • Copper

      Desogestrel-Ethinyl Estradiol

      Needs Explanation

      A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1, B2, B3, B12, C, and zinc levels. Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A. Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

      Desogestrel-Ethinyl Estradiol
      Copper
      ×
      1. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210-1 [review].
      2. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561-4.
      3. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197-8.
      4. Berg G, Kohlmeier L, Brenner H. Effect of oral contraceptive progestins on serum copper concentration. Eur J Clin Nutr 1998;52:711-5.
      5. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.
    • Copper

      Ethinyl Estradiol and Levonorgestrel

      Needs Explanation
      A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1, B2, B3, B12, C, and zinc levels. Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A. Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.
      Ethinyl Estradiol and Levonorgestrel
      Copper
      ×
      1. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210-1 [review].
      2. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561-4.
      3. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197-8.
      4. Berg G, Kohlmeier L, Brenner H. Effect of oral contraceptive progestins on serum copper concentration. Eur J Clin Nutr 1998;52:711-5.
      5. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.
    • Copper

      Ethinyl Estradiol and Norethindrone

      Needs Explanation

      A review of literature suggests that women who use OCs may experience decreased vitamin B1, B2, B3, B12, C, and zinc levels. OC use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A. OCs may interfere with manganese absorption. The clinical importance of these actions remains unclear.

      Ethinyl Estradiol and Norethindrone
      Copper
      ×
      1. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210-1 [review].
      2. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561-4.
      3. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197-8.
      4. Berg G, Kohlmeier L, Brenner H. Effect of oral contraceptive progestins on serum copper concentration. Eur J Clin Nutr 1998;52:711-5.
      5. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.
    • Copper

      Ethinyl Estradiol and Norgestimate

      Needs Explanation
      Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A. Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

       

      Ethinyl Estradiol and Norgestimate
      Copper
      ×
      1. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210-1 [review].
      2. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561-4.
      3. Berg G, Kohlmeier L, Brenner H. Effect of oral contraceptive progestins on serum copper concentration. Eur J Clin Nutr 1998;52:711-5.
      4. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.
    • Copper

      Etodolac

      Needs Explanation

      Supplementation may enhance the anti-inflammatory effects of NSAIDs while reducing their ulcerogenic effects. One study found that when various anti-inflammatory drugs were chelated with copper, the anti-inflammatory activity was increased. Animal models of inflammation have found that the copper chelate of aspirin was active at one-eighth the effective amount of aspirin. These copper complexes are less toxic than the parent compounds, as well.

      Etodolac
      Copper
      ×
      1. Sorenson JRJ. Copper chelates as possible active forms of the antiarthritic agents. J Medicinal Chem 1976;19:135-48.
    • Copper

      Ibuprofen

      Needs Explanation

      Supplementation may enhance the anti-inflammatory effects of NSAIDs while reducing their ulcerogenic effects. One study found that when various anti-inflammatory drugs were chelated with copper, the anti-inflammatory activity was increased. Animal models of inflammation have found that the copper chelate of aspirin was active at one-eighth the effective amount of aspirin. These copper complexes are less toxic than the parent compounds as well.

      Ibuprofen
      Copper
      ×
      1. Sorenson JRJ. Copper chelates as possible active forms of the antiarthritic agents. J Medicinal Chem 1976;19:135-48.
    • Copper

      Nabumetone

      Needs Explanation

      Supplementation may enhance the anti-inflammatory effects of NSAIDs while reducing their ulcerogenic effects. One study found that when various anti-inflammatory drugs were chelated with copper, the anti-inflammatory activity was increased. Animal models of inflammation have found that the copper chelate of aspirin was active at one-eighth the effective amount of aspirin. These copper complexes are less toxic than the parent compounds, as well.

      Nabumetone
      Copper
      ×
      1. Sorenson JRJ. Copper chelates as possible active forms of the antiarthritic agents. J Medicinal Chem 1976;19:135-48.
    • Copper

      Naproxen

      Needs Explanation

      Supplementation with copper may enhance the anti-inflammatory effects of NSAIDs while reducing their ulcerogenic effects. One study found that when various anti-inflammatory drugs were chelated with copper, the anti-inflammatory activity was increased. Animal models of inflammation have found that the copper chelate of aspirin was active at one-eighth the effective dose of aspirin. These copper complexes are less toxic than the parent compounds, as well.

      Naproxen
      Copper
      ×
      1. Sorenson JRJ. Copper chelates as possible active forms of the antiarthritic agents. J Medicinal Chem 1976;19:135-48.
    • Copper

      Penicillamine

      Needs Explanation

      One of the main uses of penicillamine is to reduce toxic copper deposits in people with Wilson’s disease. People taking a copper supplement can make Wilson’s disease worse and may negate the benefits of drugs used to remove copper from the body.

References

1. Rucker RB, Kosonen T, Clegg MS, et al. Copper lysyl oxidase, and extracellular matrix protein cross-linking. Am J Clin Nutr 1998;67(5 suppl):996s-1002s.

2. Sandstead HH. Understanding zinc: Recent observations and interpretations. J Lab Clin Med 1994;124:322-7.

3. Tenaud I, Sainte-Marie I, Jumbou O, et al. In vitro modulation of keratinocyte wound healing integrins by zinc, copper and manganese. Br J Dermatol 1999;140:26-34.

4. Pereira CE, Felcman J. Correlation between five minerals and the healing effect of Brazilian medicinal plants. Biol Trace Elem Res 1998;65:251-9.

5. Carlisle EM. Silicon as an essential trace element in animal nutrition. Ciba Found Symp 1986;121:123-39.

6. Leach RM. Role of manganese in mucopolysaccharide metabolism. Fed Proc 1971;30:991.

7. Rucker RB, Kosonen T, Clegg MS, et al. Copper lysyl oxidase, and extracellular matrix protein cross-linking. Am J Clin Nutr 1998;67(5 suppl):996s-1002s.

8. Davis GK, Mertz W. Copper. In: Mertz W, ed. Trace elements in human and animal nutrition, vol. 1. 5th ed. San Diego: Academic Press, 1987, 301-64 [review].

9. Klevay LM. Dietary copper: a powerful determinant of cholesterolemia. Med Hypotheses 1987;24:111-9 [review].

10. Hermann J, Chung H, Arquitt A, et al. Effects of chromium or copper supplementation on plasma lipids, plasma glucose and serum insulin in adults over age fifty. J Nutr Elderly 1998;18:27-45.

11. Little DR. Ambulatory management of common forms of anemia. Am Fam Physician 1999;59:1598-604 [review].

12. Hodges RE, Sauberlich HE, Canham JE, et al. Hematopoietic studies in vitamin A deficiency. Am J Clin Nutr 1978;31:876-85 [review].

13. Bloem MW. Interdependence of vitamin A and iron: an important association for programmes of anaemia control. Proc Nutr Soc 1995;54:501-8 [review].

14. Lane M, Alfrey CP. The anemia of human riboflavin deficiency. Blood 1965;25:432-42.

15. Orehek AJ, Kollas CD. Refractory postpartum anemia due to vitamin B6 deficiency. Ann Intern Med 1997;126(10):834-5 [letter].

16. Iwama H, Iwase O, Hayashi S, et al. Macrocytic anemia with anisocytosis due to alcohol abuse and vitamin B6 deficiency. Rinsho Ketsueki 1998;39:1127-30 [in Japanese].

17. Hirschmann JV, Raugi GJ. Adult scurvy. J Am Acad Dermatol 1999;41:895-906 [review].

18. Summerfield AL, Steinberg FU, Gonzalez JG. Morphologic findings in bone marrow precursor cells in zinc-induced copper deficiency anemia. Am J Clin Pathol 1992;97:665-8.

19. Freycon F, Pouyau G. Rare nutritional deficiency anemia: deficiency of copper and vitamin E. Sem Hop 1983;59:488-93 [review] [in French].

20. Borgna-Pignatti C, Marradi P, Pinelli L, et al. Thiamine-responsive anemia in DIDMOAD syndrome. J Pediatr 1989;114:405-10.

21. Neufeld EJ, Mandel H, Raz T, et al. Localization of the gene for thiamine-responsive megaloblastic anemia syndrome, on the long arm of chromosome 1, by homozygosity mapping. Am J Hum Genet 1997;61:1335-41.

22. Spencer JC. Direct relationship between the body's copper/zinc ratio, ventricular premature beats and sudden cardiac death. Am J Clin Nutr 1979;32:1184-5 [letter].

23. Porter KG, McMaster D, Elmes ME, Love AH. Anaemia and low serum-copper during zinc therapy. Lancet 1977;2:774 [letter].

24. Hill CH. A role of copper in elastin formation. Nutr Rev 1969;27:99-100 [review].

25. Greene FL, Lamb LS, Barwick M, Pappas NJ. Effect of dietary copper on colonic tumor production and aortic integrity in the rat. J Surg Res 1987;42:503-12.

26. Vanhooser SL, Stair E, Edwards WC, et al. Aortic rupture in ostrich associated with copper deficiency. Vet Hum Toxicol 1994;36:226-7.

27. Guenthner E, Carlson CW, Emerick RJ. Copper salts for growth stimulation and alleviation of aortic rupture losses in turkeys. Poult Sci 1978;57:1313-24.

28. Tilson MD. Decreased hepatic copper levels. A possible chemical marker for the pathogenesis of aortic aneurysms in man. Arch Surg 1982;117:1212-3.

29. Tilson MD, Davis G. Deficiencies of copper and a compound with ion-exchange characteristics of pyridinoline in skin from patients with abdominal aortic aneurysms. Surgery 1983;94:134-41.

30. Senapati A, Carlsson LK, Fletcher CD, et al. Is tissue copper deficiency associated with aortic aneurysms? Br J Surg 1985;72:352-3.

31. Dubick MA, Hunter GC, Casey SM, Keen CL. Aortic ascorbic acid, trace elements, and superoxide dismutase activity in human aneurysmal and occlusive disease. Proc Soc Exp Biol Med 1987;184:138-43.

32. Jaakkola P, Hippelainen M, Kantola M. Copper and zinc concentrations of abdominal aorta and liver in patients with infrarenal abdominal aortic aneurysm or aortoiliacal occlusive disease. Ann Chir Gynaecol 1994;83:304-8.

33. Eaton-Evans J, McIlrath EM, Jackson WE, et al. Copper supplementation and bone-mineral density in middle-aged women. Proc Nutr Soc 1995;54:191A.

34. Baker A, Turley E, Bonham MP, et al. No effect of copper supplementation on biochemical markers of bone metabolism in healthy adults. Br J Nutr 1999;82:283-90.

35. Abraham GE, Grewal H. A total dietary program emphasizing magnesium instead of calcium. J Reprod Med 1990;35:503-7.

36. Singh A, Failla ML, Deuster PA. Exercise-induced changes in immune function: effects of zinc supplementation. J Appl Physiol 1994;76:2298-303.

37. Lukaski HC. Magnesium, zinc, and chromium nutriture and physical activity. Am J Clin Nutr 2000;72:585S-93S [review].

38. Van Loan MD, Sutherland B, Lowe NM, et al. The effects of zinc depletion on peak force and total work of knee and shoulder extensor and flexor muscles. Int J Sport Nutr 1999;9:125-35.

39. Manore MM. Dietary recommendations and athletic menstrual dysfunction. Sports Med 2002;32:887-901 [review].

40. Micheletti A, Rossi R, Rufini S. Zinc status in athletes: relation to diet and exercise. Sports Med 2001;31:577-82 [review].

41. Krotkiewski M, Gudmundsson M, Backstrom P, Mandroukas K. Zinc and muscle strength and endurance. Acta Physiol Scand 1982;116:309-11.

42. Khaled S, Brun JF, Cassanas G, et al. Effects of zinc supplementation on blood rheology during exercise. Clin Hemorheol Microcirc 1999;20:1-10.

43. Bush IM, Berman E, Nourkayhan S, et al. Zinc and the prostate. Presented at the annual meeting of the American Medical Association Chicago, 1974.

44. Fahim MS, Fahim Z, Der R, Harman J. Zinc treatment for reduction of hyperplasia of prostate. Fed Proc 1976;35(3):361.

45. Anderson RA et al. Chromium supplementation of humans with hypoglycemia. Fed Proc 1984;43:471.

46. Stebbing JB et al. Reactive hypoglycemia and magnesium. Magnesium Bull 1982;2:131-4.

47. Shansky A. Vitamin B3 in the alleviation of hypoglycemia. Drug Cosm Ind 1981;129(4):68-69,104-5.

48. Gaby AR, Wright JV. Nutritional regulation of blood glucose. J Advancement Med 1991;4:57-71.

49. DiSilvestro RA, Marten J, Skehan M. Effects of copper supplementation on ceruloplasmin and copper­zinc superoxide dismutase in free­living rheumatoid arthritis patients. J Am Coll Nutr 1992;11:177-80.

50. Jones AA, DiSilvestro RA, Coleman M, Wagner TL. Copper supplementation of adult men: effects on blood copper enzyme activities and indicators of cardiovascular disease risk. Metabolism 1997;46:1380-3.

51. Medical News. Copper boosts activity of anti-inflammatory drugs. JAMA 1974;229:1268-9.

52. Sorenson JRJ. Copper complexes—a unique class of anti­arthritic drugs. Progress Med Chem 1978;15:211-60 [review].

53. Walker WR, Keats DM. An investigation of the therapeutic value of the ‘copper bracelet'—dermal assimilation of copper in arthritic/rheumatoid conditions. Agents Actions 1976;6:454-9.

54. Blake DR, Lunec J. Copper, iron, free radicals and arthritis. Brit J Rheumatol 1985;24:123-7 [editorial].

55. Aoyogi S, Baker DH. Bioavailability of copper in analytical-grade and feed-grade inorganic copper sources when fed to provide copper at levels below the chicks requirement. Poult Sci 1993;72:1075-83.

56. Baker DH, Odle J, Funk MA, Wieland TM. Bioavailability of copper in cupric oxide, cuprous oxide and in a copper-lysine complex. Poult Sci 1991;70:177-9.

57. Cromwell GL, Stahly TS, Moneque HJ. Effects of source and level of copper on performance and liver copper stores in weanling pigs. J Anim Sci 1989;67:2996-3002.

58. Ledoux DR, Henry PR, Ammerman CB, et al. Estimation of the relative bioavailability of inorganic copper sources for chicks using tissue uptake of copper. J Anim Sci 1991;69:215-22.

59. Baker DH. Cupric oxide should not be used as a copper supplement for either animals or humans. J Nutr 1999;129:2278-9.

60. Sandstead HH. Requirements and toxicity of essential trace elements, illustrated by zinc and copper. Am J Clin Nutr 1995;61(suppl):621S-24S [review].

61. Broun ER. Greist A, Tricot G, Hoffman R. Excessive zinc ingestion. A reversible cause of sideroblastic anemia and bone marrow depression. JAMA 1990;264:1441-3.

62. Jacob RA, Skala JH, Omaye ST, Turnlund JR. Effect of varying ascorbic acid intakes on copper absorption and ceruloplasmin levels of young men. J Nutr 1987;117:2109-15.

63. Ford ES. Serum copper concentration and coronary heart disease among US adults. Am J Epidemiol 2000;151:1182-8.

64. Youssef A, Wood B, Baron DN. Serum copper: a marker of disease activity in rheumatoid arthritis. J Clin Pathol 1983;36:14-17.

Copyright © 2020 TraceGains, Inc. All rights reserved.

Learn more about TraceGains, the company.

The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2020.

Copyright © 2020 TraceGains, Inc. All rights reserved.

The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2020.