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Nutritional Supplement

Charcoal

  • Negative Interactions

    1
    • Charcoal

      Ipecac

      Reduces Effectiveness

      In the treatment of certain poisonings, activated charcoal is used to reduce the amount of poison absorbed into the body. Some references have suggested that people avoid giving ipecac and activated charcoal together. However, controlled studies have shown that activated charcoal may not completely block the effects of ipecac, and that the combination is effective when activated charcoal is given ten minutes after ipecac treatment. Until more information is available, individuals should probably wait to give activated charcoal until after the ipecac-induced vomiting stops.

      Ipecac
      Charcoal
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      1. Olin BR, ed. Miscellaneous Products, Antidotes. In Drug Facts and Comparisons. St. Louis, MO: Facts and Comparisons, 1993, 2695.
      2. Krenzelok EP, Freeman GE, Pasternak S. Preserving the emetic effect of syrup of ipecac with concurrent activated charcoal administration: a preliminary study. J Toxicol Clin Toxicol 1986;24:159-66.
      3. Freeman GE, Pasternak S, Krezelok EP. A clinical trial using syrup of ipecac and activated charcoal concurrently. Ann Emerg Med 1987;16:164-6.

References

1. Krasopoulos JC, De Bari VA, Needle MA. The adsorption of bile salts on activated carbon. Lipids 1980;15:365-70.

2. Tishler PV, Winston SH, Bell SM. Correlative studies of the hypocholesterolemic effect of a highly activated charcoal. Methods Find Exp Clin Pharmacol 1987;9:799-806.

3. Neuvonen PJ, Kuusisto P, Vapaatalo H, Manninen V. Activated charcoal in the treatment of hypercholesterolaemia: dose-response relationships and comparison with cholestyramine. Eur J Clin Pharmacol 1989;37:225-30.

4. Park GD, Spector R, Kitt TM. Superactivated charcoal versus cholestyramine for cholesterol lowering: a randomized cross-over trial. J Clin Pharmacol 1988;28:416-9.

5. Neuvonen PJ, Kuusisto P, Manninen V, et al. The mechanism of the hypocholesterolaemic effect of activated charcoal. Eur J Clin Invest 1989;19:251-4.

6. Hoekstra JB, Erkelens DW. No effect of activated charcoal on hyperlipidaemia. A double-blind prospective trial. Neth J Med 1988;33:209-16.

7. Ohge H, Furne JK, Springfield J, et al. Effectiveness of devices purported to reduce flatus odor. Am J Gastroenterol 2005;100:397-400.

8. Suarez FL, Springfield J, Levitt MD. Identification of gases responsible for the odour of human flatus and evaluation of a device purported to reduce this odour. Gut 1998;43:100-4.

9. Hall RG Jr, Thompson H, Strother A. Effects of orally administered activated charcoal on intestinal gas. Am J Gastroenterol 1981;75:192-6.

10. Suarez FL, Furne J, Springfield J, Levitt MD. Failure of activated charcoal to reduce the release of gases produced by the colonic flora. Am J Gastroenterol 1999;94:208-12.

11. Position statement and practice guidelines on the use of multi-dose activated charcoal in the treatment of acute poisoning. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists. J Toxicol Clin Toxicol 1999;37:731-51.

12. Hift RJ, Todd G, Meissner PN, Kirsch RE. Administration of oral activated charcoal in variegate porphyria results in a paradoxical clinical and biochemical deterioration. Br J Dermatol 2003;149:1266-9.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2020.

Copyright © 2020 TraceGains, Inc. All rights reserved.

The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2020.