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Health Encyclopedia

Nutritional Supplement

Butterbur

  • Allergy and Lung Support

    Hay Fever

    Studies have shown butterbur extract to be effective at reducing hay fever symptoms.
    Hay Fever
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    Two double-blind studies have compared butterbur extract to standard antihistamine drugs in people with hay fever. The first compared it with the drug cetirizine (Zyrtec) and found the drug and butterbur extract relieved symptoms equally well. However, cetirizine caused significantly more adverse effects, including a high rate of drowsiness.6 The second study compared butterbur extract with fexofenadine (Allegra) and placebo. Butterbur extract was as effective as fexofenadine at relieving symptoms, and both were significantly better than placebo.7

    People with hay fever had better symptomatic relief and reductions in levels of immune cells associated with allergic reactions (eosinophils) when treated with an herbal formula containing horny goat weed compared with a formula without horny goat weed and another herb by itself.8 Traditionally 5 grams (1 tsp) of horny goat weed is taken three times per day, usually after being simmered (decocted) in 250 ml (1 pint) of water for 10 to 15 minutes.9

    In a double-blind study, an extract of the butterbur plant (Petasites hybridus) was significantly more effective than a placebo at improving symptoms in people suffering from seasonal allergic rhinitis.10 The study used a preparation standardized to contain 8 mg of total petasin per tablet. One tablet was administered either two or three times a day for two weeks; the larger amount was found to be more effective than the smaller amount.

    Asthma

    In one study, asthma patients taking inhaled steroids who also took butterbur extract saw significant improvement in airflow.
    Asthma
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    In a double-blind study, adult asthma patients taking inhaled steroids took either butterbur extract or placebo.11 There was a significantly greater improvement in airflow in the group that took butterbur extract compared with those who took placebo. A study without a control group showed that people with mild asthma, most still taking various anti-asthma medications, had better airflow but actually showed some evidence of having more frequent asthma attacks when they took butterbur.12 Therefore more rigorous studies are needed to know how effective butterbur is in people with asthma.

  • Pain Management

    Migraine Headache

    Butterbur extract has been shown to significantly reduce the frequency of migraine attacks.
    Migraine Headache
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    Double-blind trials have demonstrated that butterbur extract can reduce the frequency of migraine attacks significantly better than placebo.13,14 One study has also shown it helps reduce the frequency of migraine headaches in children and adolescents, though there was no control group so it is not as clear just how effective butterbur extract is in this population.15 In a double-blind trial, supplementing with an extract of butterbur (Petasites hybridus) for four months was significantly more effective than a placebo at reducing the frequency of migraine attacks.16 The amount of butterbur found to be effective was 75 mg twice a day of an extract standardized to contain at least 15% petasins. A smaller amount (50 mg twice a day) was ineffective. The most common side effect was burping.

What Are Star Ratings?
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Reliable and relatively consistent scientific data showing a substantial health benefit.
Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

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Traditional Use (May Not Be Supported by Scientific Studies)

Traditionally the entire plant was used as a demulcent to soothe a dry, spasmodic cough.17 It was primarily made into a tea, and used only for short periods of time. Using the herb as a tea may have helped reduce the liver’s exposure to butterbur's toxic compounds, as they are not normally water soluble.

References

1. Wang GJ, Shum AY, Lin YL, et al. Calcium channel blockade in vascular smooth muscle cells: Major hypotensive mechanism of S-petasin, a hypotensive sesquiterpene from Petasites formosanus. J Pharmacol Exp Ther 2001;297:240-6.

2. Thomet OA, Schapowal A, Heinisch IV, et al. Anti-inflammatory activity of an extract of Petasites hybridus in allergic rhinitis. Int Immunopharmacol 2002;2:997-1006.

3. Lipton RB, Gobel H, Einhaupl KM, et al. Petasites hybridus root (butterbur) is an effective preventive treatment for migraine. Neurology 2004;63:2240-4.

4. REF:Lee DK, Haggart K, Robb FM, Lipworth BJ. Butterbur, a herbal remedy, confers complementary anti-inflammatory activity in asthmatic patients receiving inhaled corticosteroids. Clin Exp Allergy 2004; 34:110-4.

5. Ziolo G, Samochewiec L. Study on clinical properties and mechanism of action of petasites in bronchial asthma and chronic obstructive bronchitis. Pharm Acta Helv 1998;72:378-80.

6. Schapowal A, Petasites Study Group. Randomised controlled trial of butterbur and cetirizine for treating seasonal allergic rhinitis. BMJ 2002;324:144-6.

7. Lee DK, Gray RD, Robb FM, et al. A placebo-controlled evaluation of butterbur and fexofenadine on objective and subjective outcomes in perennial allergic rhinitis. Clin Exp Allergy 2004;34:646-9.

8. Yu YJ. Effect of tian-huang-ling granule in the treatment of allergic rhinitis. Zhong Xi Yi Jie He Za Zhi 1989;9:720-1, 708 [in Chinese].

9. Chen JK, Chen TT. Chinese Medical Herbology and Pharmacology. City of Industry, CA: Art of Medicine Press, Inc., 2003.

10. Schapowal A; Petasites Study Group. Butterbur Ze339 for the treatment of intermittent allergic rhinitis: dose-dependent efficacy in a prospective, randomized, double-blind, placebo-controlled study. Arch Otolaryngol Head Neck Surg 2004;130:1381-6.

11. REF:Lee DK, Haggart K, Robb FM, Lipworth BJ. Butterbur, a herbal remedy, confers complementary anti-inflammatory activity in asthmatic patients receiving inhaled corticosteroids. Clin Exp Allergy 2004; 34:110-4.

12. Danesch UC. Petasites hybridus (butterbur root) extract in the treatment of asthma—an open trial. Altern Med Rev 2004;9:54-62.

13. Diener HC, Rahlfs VW. Danesch U. The first placebo-controlled trial of a special butterbur extract for the prevention of migraine: reanalysis of efficacy criteria. Eur Neurol 2004;51:89–97.

14. Grossmann M, Schmidramsl H. An extract of Petasites hybridus is effective in the prophylaxis of migraine. Int J Clin Pharmacol Ther2000;38:430-5.

15. Pothmann R, Danesch U. Migraine prevention in children and adolescents: results of an open study with a special butterbur root extract. Headache2005;45:196-203.

16. Lipton RB, Gobel H, Einhaupl KM, et al. Petasites hybridus root (butterbur) is an effective preventive treatment for migraine. Neurology 2004;63:2240-4.

17. Moore M. Medicinal Plants of the Pacific West. Santa Fe NM: Red Crane Books, 1993.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2020.

Copyright © 2020 TraceGains, Inc. All rights reserved.

The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2020.