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Nutritional Supplement

Biotin

Biotin, a water-soluble B vitamin, acts as a coenzyme in the metabolism of protein, fats, and carbohydrates.

References

1. Maebashi M, Makino Y, Furukawa Y, et al. Therapeutic evaluation of the effect of biotin on hyperglycemia in patients with non-insulin dependent diabetes mellitus. J Clin Biochem Nutr 1993;14:211–8

2. Revilla-Monsalve C, Zendejas-Ruiz I, Islas-Andrade S, et al. Biotin supplementation reduces plasma triacylglycerol and VLDL in type 2 diabetic patients and in nondiabetic subjects with hypertriglyceridemia. Biomed Pharmacother 2006;60:182–5.

3. Koutsikos D, Agroyannis B, Tzanatos-Exarchou H. Biotin for diabetic peripheral neuropathy. Biomed Pharmacother 1990;44:511–4.

4. Singer G, Geohas J. The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized trial. Diabetes Technol Ther 2006;8:636–43.

5. Albarracin C, Fuqua B, Geohas J, et al. Combination of chromium and biotin improves coronary risk factors in hypercholesterolemic type 2 diabetes mellitus: a placebo-controlled, double-blind randomized clinical trial. J Cardiometab Syndr 2007;2:91–7.

6. Geohas J, Daly A, Juturu V, et al. Chromium picolinate and biotin combination reduces atherogenic index of plasma in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial. Am J Med Sci 2007;333:145–53.

7. Albarracin C, Fuqua B, Evans J, Goldfine I. Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes. Diabetes Metab Res Rev 2008;24:41–51.

8. McCarty M. In type 1 diabetics, high-dose biotin may compensate for low hepatic insulin exposure, promoting a more normal expression of glycolytic and gluconeogenic enyzymes and thereby aiding glycemic control. Med Hypotheses 2016;95:45–8.

9. Coggeshall J, Heggers J, Robson M, Baker H. Biotin Status and Plasma Glucose in Diabetics. Ann NY Acad Sci 1985;447:389–92.

10. Hemmati M, Babaei H, Abdolsalehei M. Survey of the effect of biotin on glycemic control and plasma lipid concentrations in type 1 diabetic patients in kermanshah in iran (2008-2009). Oman Med J 2013;28:195–8.

11. Koutsikos D, Agroyannis B, Tzanatos-Exarchou H. Biotin for diabetic peripheral neuropathy. Biomed Pharmacother 1990;44:511–4.

12. Mock DM, Quirk JG, Mock NI. Marginal biotin deficiency during normal pregnancy. Am J Clin Nutr 2002;75:295-9.

13. Nisenson A. Seborrheic dermatitis of infants: treatment with biotin injections for the nursing mother. Pediatrics 1969;44:1014-6.

14. Messaritakis J, Kattamis C, Karabula C, Matsaniotis N. Generalized seborrheic dermatitis: clinical and therapeutic data of 25 patients. Arch Dis Child 1975;50:871-4.

15. Nisenson A. Seborrheic dermatits of infants and Leiner's disease: a biotin deficiency. J Pediatr 1957;51:537-48.

16. Keipert JA. Oral use of biotin in seborrheic dermatitis of infancy: a controlled trial. Med J Aust 1976;1:584-5.

17. Erlichman M, Goldstein R, Levi E, et al. Infantile flexural seborrheic dermatitis. Neither biotin nor essential fatty acid deficiency. Arch Dis Child 1981;56:560-2.

18. Mock DM, Quirk JG, Mock NI. Marginal biotin deficiency during normal pregnancy. Am J Clin Nutr 2002;75:295-9.

19. Nisenson A. Seborrheic dermatitis of infants: treatment with biotin injections for the nursing mother. Pediatrics 1969;44:1014-6.

20. Messaritakis J, Kattamis C, Karabula C, Matsaniotis N. Generalized seborrheic dermatitis: clinical and therapeutic data of 25 patients. Arch Dis Child 1975;50:871-4.

21. Nisenson A. Seborrheic dermatits of infants and Leiner's disease: a biotin deficiency. J Pediatr 1957;51:537-48.

22. Keipert JA. Oral use of biotin in seborrheic dermatitis of infancy: a controlled trial. Med J Aust 1976;1:584-5.

23. Erlichman M, Goldstein R, Levi E, et al. Infantile flexural seborrheic dermatitis. Neither biotin nor essential fatty acid deficiency. Arch Dis Child 1981;56:560-2.

24. Floersheim GL. Treatment of brittle fingernails with biotin. Z Hautkr 1989;64:41-8 [in German].

25. Hochman LG, Scher RK, Meyerson MS. Brittle nails: response to daily biotin supplementation. Cutis 1993;51:303-5.

26. Mock DM. Biotin. In: Shils ME, Olson JA, Shike M, Ross, AC (eds). Modern Nutrition in Health and Disease. Baltimore: Williams and Wilkins, 1999, 459-66.

27. Zempleni J, Mock DM. Biotin biochemistry and human requirements. J Nutr Biochem 1999;10:128-38 [review].

28. Coggeshall JC, Heggers JP, Robson MC, Baker H. Biotin status and plasma glucose in diabetics. Ann NY Acad Sci 1985;447:389-93.

29. Koutsikos D, Agroyannis B, Tzanatos-Exarchou H. Biotin for diabetic peripheral neuropathy. Biomed Pharmacother 1990;44:511–4.

30. Hochman LG, Scher RK, Meyerson MS. Brittle nails: response to daily biotin supplementation. Cutis 1993;51:303-5.

31. Mock DM. Skin manifestations of biotin deficiency. Semin Dermatol 1991;10:296-302.

32. Said HM, Redha R, Nylander W. Biotin transport in the human intestine: inhibition by anticonvulsant drugs. Am J Clin Nutr 1989;49:127-31.

33. Zempleni J, Mock DM. Biotin biochemistry and human requirements. J Nutr Biochem 1999;10:128-38 [review].

34. Zempleni J, Mock DM. Marginal biotin deficiency is teratogenic. Proc Soc Exp Biol Med 2000;223:14-21 [review].

35. Mock DM, Quirk JG, Mock NI. Marginal biotin deficiency during normal pregnancy. Am J Clin Nutr 2002;75:295-9.

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The information presented by Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2020.

Copyright © 2020 Healthnotes, Inc. All rights reserved.

The information presented by Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2020.