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Nutritional Supplement

Amylase Inhibitors

  • Weight Management

    Obesity

    Amylase inhibitors contain substances that prevent dietary carbohydrates from being absorbed by the body and may aid in weight loss.
    Obesity
    ×
    Amylase inhibitors are also known as starch blockers because they contain substances that prevent dietary starches from being absorbed by the body. Starches are complex carbohydrates that cannot be absorbed unless they are first broken down by the digestive enzyme amylase and other, secondary, enzymes.10,11 When starch blockers were first developed years ago, they were found not to be potent enough to prevent the absorption of a significant amount of carbohydrate.12,13,14,15 Recently, highly concentrated starch blockers have been shown to be more effective,16,17,18 but no published human studies exist investigating their usefulness for weight loss.
  • Blood Sugar and Diabetes Support

    Type 2 Diabetes

    Amylase inhibitors from various medicinal herbs and plant foods may reduce the usual after-meal rise in blood glucose levels in people with diabetes.
    Type 2 Diabetes
    ×
    Amylase inhibitors are substances that reduce the activity of amylase, the digestive enzyme required to break down dietary starches into absorbable glucose. Many plants and plant foods, including vegetables and legumes, contain amylase-inhibiting compounds that may be useful in preventing and treating type 2 diabetes.19,20,21 For example, adding beans to a serving of rice reduces the rise in blood glucose, an effect that may be due in part to the amylase-inhibiting action of beans.22 A review of clinical trials reported that taking 1,500 to 3,000 mg of an amylase-inhibiting extract from white beans (Phaseolus vulgaris) before meals has been shown in multiple studies to reduce post-meal blood glucose levels and may promote weight loss.23 However, this review and most of the studies it included were funded by the manufacturer of the bean extract. Its usefulness as a therapy for type 2 diabetes has not been tested.

    Type 1 Diabetes

    Amylase inhibitors, taken with meals, may reduce the usual rise in blood sugar levels in people with diabetes.
    Type 1 Diabetes
    ×
    Substances that inhibit amylase, the digestive enzyme required to break down dietary starches into absorbable glucose units, can reduce the usual post-meal rise in blood sugar levels in both healthy people and people with diabetes. Amylase inhibitors occur naturally in foods such as whole grains and legumes, as well as in many culinary herbs and spices and medicinal herbs, possibly contributing to their anti-diabetic effects.24,25 While some food and herbal extracts with amylase-inhibiting effects have shown promise in animal research, their benefits for type 1 diabetes await confirmation in clinical trials.26
What Are Star Ratings?
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Reliable and relatively consistent scientific data showing a substantial health benefit.
Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

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References

1. Marshall JJ, Lauda CM. Purification and properties of phaseolamin, an inhibitor of alpha-amylase, from the kidney bean, Phaseolus vulgaris. J Biol Chem 1975;250:8030-7.

2. Choudhury A, Maeda K, Murayama R, DiMagno EP. Character of a wheat amylase inhibitor preparation and effects on fasting human pancreaticobiliary secretions and hormones. Gastroenterology 1996;111:1313-20.

3. Bo-Linn GW, Santa Ana CA, Morawski SG, Fordtran JS. Starch blockers—their effect on calorie absorption from a high-starch meal. N Engl J Med 1982;307:1413-6.

4. Hollenbeck CB, Coulston AM, Quan R, et al. Effects of a commercial starch blocker preparation on carbohydrate digestion and absorption: in vivo and in vitro studies. Am J Clin Nutr 1983;38:498-503.

5. Garrow JS, Scott PF, Heels S, et al. A study of 'starch blockers' in man using 13C-enriched starch as a tracer. Hum Nutr Clin Nutr 1983;37:301-5.

6. Carlson GL, Li BU, Bass P, Olsen WA. A bean alpha-amylase inhibitor formulation (starch blocker) is ineffective in man. Science 1983;219:393-5.

7. Brugge WR, Rosenfeld MS. Impairment of starch absorption by a potent amylase inhibitor. Am J Gastroenterol 1987;82:718-22.

8. Boivin M, Zinsmeister AR, Go VL, DiMagno EP. Effect of a purified amylase inhibitor on carbohydrate metabolism after a mixed meal in healthy humans. Mayo Clin Proc 1987;62:249-55.

9. Layer P, Carlson GL, DiMagno EP. Partially purified white bean amylase inhibitor reduces starch digestion in vitro and inactivates intraduodenal amylase in humans. Gastroenterology 1985;88:1895-902.

10. Marshall JJ, Lauda CM. Purification and properties of phaseolamin, an inhibitor of alpha-amylase, from the kidney bean, Phaseolus vulgaris. J Biol Chem 1975;250:8030-7.

11. Choudhury A, Maeda K, Murayama R, DiMagno EP. Character of a wheat amylase inhibitor preparation and effects on fasting human pancreaticobiliary secretions and hormones. Gastroenterology 1996;111:1313-20.

12. Bo-Linn GW, Santa Ana CA, Morawski SG, Fordtran JS. Starch blockers—their effect on calorie absorption from a high-starch meal. N Engl J Med 1982;307:1413-6.

13. Hollenbeck CB, Coulston AM, Quan R, et al. Effects of a commercial starch blocker preparation on carbohydrate digestion and absorption: in vivo and in vitro studies. Am J Clin Nutr 1983;38:498-503.

14. Garrow JS, Scott PF, Heels S, et al. A study of 'starch blockers' in man using 13C-enriched starch as a tracer. Hum Nutr Clin Nutr 1983;37:301-5.

15. Carlson GL, Li BU, Bass P, Olsen WA. A bean alpha-amylase inhibitor formulation (starch blocker) is ineffective in man. Science 1983;219:393-5.

16. Brugge WR, Rosenfeld MS. Impairment of starch absorption by a potent amylase inhibitor. Am J Gastroenterol 1987;82:718-22.

17. Boivin M, Zinsmeister AR, Go VL, DiMagno EP. Effect of a purified amylase inhibitor on carbohydrate metabolism after a mixed meal in healthy humans. Mayo Clin Proc 1987;62:249-55.

18. Layer P, Carlson GL, DiMagno EP. Partially purified white bean amylase inhibitor reduces starch digestion in vitro and inactivates intraduodenal amylase in humans. Gastroenterology 1985;88:1895-902.

19. Liu D, Gao H, Tang W, Nie S. Plant non-starch polysaccharides that inhibit key enzymes linked to type 2 diabetes mellitus. Ann N Y Acad Sci 2017;1401:28–36.

20. Tiwari A. Revisiting "Vegetables" to combat modern epidemic of imbalanced glucose homeostasis. Pharmacogn Mag 2014;10:S207–13.

21. Wang H, Liu T, Huang D. Starch hydrolase inhibitors from edible plants. Adv Food Nutr Res 2013;70:103–36.

22. Thompson S, Winham D, Hutchins A. Bean and rice meals reduce postprandial glycemic response in adults with type 2 diabetes: a cross-over study. Nutr J 2012;11:23.

23. Barrett M, Udani J. A proprietary alpha-amylase inhibitor from white bean (Phaseolus vulgaris): a review of clinical studies on weight loss and glycemic control. Nutr J 2011;10:24.

24. Alam F, Shafique Z, Amjad S, et al. Enzymes inhibitors from natural sources with antidiabetic activity: A review. Phytother Res 2019;33:41–54.

25. Takahama U, Hirota S. Interactions of flavonoids with alpha-amylase and starch slowing down its digestion. Food Funct 2018;9:677–87.

26. Najafian M, Ebrahim-Habibi A, Yaghmaei P, et al. Core structure of flavonoids precursor as an antihyperglycemic and antihyperlipidemic agent: an in vivo study in rats. Acta Biochim Pol 2010;57:553–60.

27. Boivin M, Zinsmeister AR, Go VL, DiMagno EP. Effect of a purified amylase inhibitor on carbohydrate metabolism after a mixed meal in healthy humans. Mayo Clin Proc 1987;62:249-55.

28. Boivin M, Flourie B, Rizza RA, et al. Gastrointestinal and metabolic effects of amylase inhibition in diabetics. Gastroenterology 1988;94:387-94.

Copyright © 2020 TraceGains, Inc. All rights reserved.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2020.

Copyright © 2020 TraceGains, Inc. All rights reserved.

The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2020.